The Football Association is looking to find out why so many professional footballers suffer from the condition, which causes people with Down syndrome to have difficulties walking or communicating.
The FA has set up a team to examine the issue and the findings will be analysed by a group of experts.
Down syndrome is caused by a mutation in the gene that causes the brain to be more like a tube, rather than a straight line.
The condition can lead to hearing loss and intellectual disability, along with behavioural problems.
Some of the players have been seen being given up for adoption by their families.
The players’ families have been inundated with calls and emails, with some players refusing to speak to media.
Some are also refusing to sign contracts to play in the league.
A petition calling for a full inquiry has attracted more than 2,000 signatures.
BBC Sport’s Paul Jones investigates why so few professional football players have Down syndrome.